@charset "utf-8";

@import url("fonts.css");
@import url("colorbox/hcp_colorbox.css");

/* Mobile Layout: 600px and below. */
@import url("hcp_mobile.css") only screen and (max-width:600px);

/* ******************** ------------------------- HTML5 DEFINITIONS ------------------------- ******************** */
article,
aside,
details,
figcaption,
figure,
footer,
header,
hgroup,
nav,
section {
    display: block;
}

audio,
canvas,
video {
    display: inline-block;
    *display: inline;
    *zoom: 1;
}

/* ******************** ------------------------- IMAGE SCALING ------------------------- ******************** */

img {
	max-width: 100%;
}

/* ******************** ------------------------- ELEMENT RESET ------------------------- ******************** */
* {
	margin: 0;
	padding: 0;
}

/* apply a natural box layout model to all elements */
* { -moz-box-sizing: border-box; -webkit-box-sizing: border-box; box-sizing: border-box; }

html, body {
	height: 100%;
	-webkit-text-size-adjust: 100%; /* Prevent font scaling in landscape while allowing user zoom */
}

body {
	font-size: 16px;
	width: 100%;
}

h1,
h2,
h3,
h4,
h5 {
	font-weight: normal;
}

ul,
ol {
	padding-left: 15px;
}

ul li ul,
ol li ul {
	margin-bottom: 0px;
	padding-top: 10px;
}
	
ul.dash li {
	list-style-type: none;
	position: relative;
	padding-left: 5px;
}

ul.dash li::before {
	position: absolute;
	left: -15px;
	content: "\2014";
}
ul.romannumerals {
    list-style-type: lower-roman;
}
	
p {
	padding-bottom: 10px;
}

table {
	border-collapse: collapse;
	border-spacing: 0;
}

a {
	color: #920075;
	text-decoration: none;
}

a:hover {
	color: #920075;
	text-decoration: underline;
}

a:focus {
	outline: 0;
}

a img {
	border: 0;
}

form {
    display: inline;
}

input[type="text"],
input[type="password"],
textarea,
select {
	display: inline;
	outline: none;
}

textarea {
	resize: none;
}

button {
	overflow: visible; /* need for IE's mishandling of buttons grrrrrrrrrrrrrr */
	width: auto; /* need for IE's mishandling of buttons grrrrrrrrrrrrrr */
}

em {
	font-style: italic;
}

strong {
	font-weight: bold;
}


/* ******************** ------------------------- SHARED ELEMENTS ------------------------- ******************** */

/* ---------- ASSORTED ---------- */
.accessiblity 	{ display: none; }
.clear 			{ clear: both; }
.clearfix:after { visibility: hidden; display: block; font-size: 0; content: " "; clear: both; height: 0;}
.hide 			{ display: none !important; }
.indent			{ padding-left: 20px; }
.invisibile		{ visibility: hidden; }
.left 			{ float: left; }
.right 			{ float: right; }
.line-break 	{ display: block; }
.nobreak		{ white-space:nowrap; }
.break			{ word-wrap: break-word; }
.no-margin		{ margin-bottom: 0px; }
.note			{ font-size: 0.750em; line-height:1.2;}
.caption		{ font-size: 0.750em; line-height:1.2;}
.right 			{ float: right; }
.show 			{ display: block !important; }
.visible		{ visibility: visible; }
.vspacer		{ height: 20px; }
.reg			{ font-size: 60%; line-height: 50%; vertical-align: 120%; font-family:arial; }
.small_caps		{ font-variant: small-caps; }
.superscript 	{ font-size: 64%; line-height: 55%; vertical-align: 90%; white-space: nowrap; }
.subscript 		{ font-size: 64%; bottom: -3px; position: relative; }
.col			{ float: left; }
.center			{ text-align:center; }
.hang 			{ float: left; margin-left: -6px; margin-top: 3px; }
.hang.ast 		{ margin-top: 0px; }


/* -------------------- TABLES -------------------- */
.table_wrapper,
.chart_wrapper {
	width: 100%;
	border-bottom: 25px solid #19719c;
	background: rgba(255,255,255,.5);
	position: relative;
}

.table_head, 
.chart_head {
	font: 1.125em/1em "DIN Next W01 Medium";
	color: #fff;
	text-align: center;
	background: #19719c;
	padding: 10px 0;
}

.table_content,
.chart_content {
	width: 100%;
	padding: 0 4% 38px;
	border: 2px solid #57585b;
	border-top: none;
	border-bottom: none;
}

table {
	width: 100%;
	border-collapse: collapse;
	color: #231f20;
	font: 1em/1em "DIN Next W01 Regular";
}

td, th {
	padding: 8px 10px 6px;
	border: 1px solid #fff;
	text-align: center;
}

th {
	background-color: #fff;
}

th:nth-of-type(odd) {
	color: #6d6e71;
}

th:nth-of-type(even) {
	color: #005187;
}

thead tr:nth-of-type(2) {
	background: #fff;
	border: none;
	color: #003763;
}

td:first-child {
	text-align: left;
}


/* -------------------- COLUMN TEXT COLORS -------------------- */
tbody td:nth-of-type(2),
tbody td:nth-of-type(4) {
	color: #005187;			/* blue */
	font-family: "DIN Next W01 Bold";
}

tbody td:nth-of-type(3),
tbody td:nth-of-type(5) {
	font-family: "DIN Next W01 Bold";
	color: #6d6e71;
}

.section_head {
	background: rgba(200,212,229,.5);	/* light gray */
	color: #005187;
	font-family: "DIN Next W01 Bold";
}

.section_head td {
}

.n_value {
	display: block;
}


/* Desktop and Tablet Layout: 769px to a max of 1360px. */

@media only screen and (min-width: 601px) {

body{
	background: #2c72d5 url('../images/bg_hcp.jpg') top center no-repeat;
	background-size: cover;
}

#wrapper {
	width: 100%;
	color: #41306d;
	background: url('../images/whales.png') top left no-repeat;
}

#header {
	background:#fff;
	clear: both;
	width: 100%;
	height: 110px;
	display: block;
}

#header_inner {
	margin: 0 auto;
	display: block;
	width: 80.58823529411765%;
	height: 90px;
	padding-bottom: 20px;
}

#header_logo {
	float: left;
	width: 24%;
	display: block;
	padding-top: 20px;
	margin: 0 2.0625% 0 0;
}

#utility_nav {
	float: left;
	width: 58.60416666666667%;
	display: block;
	font-family:'DIN Next W01 Regular';
	position:relative;
	height:110px;
}

	ul#utility_links {
		list-style-type: none;
		position: absolute; /*this is for stacking to work right*/
		bottom: 18px;
		left: 0;
	}
	
	ul#utility_links li {
		display: inline-block;
		font-size: 0.813em /*13px*/;
		padding: 0 2px 0 5px;
		border-left: 1px solid #d7d7d7;
	}
	.us_site {
		bottom: 60px;
		position: absolute;
		right: 0;
		padding-left:15px;
	}
	ul#utility_links li#link_patient {
		border: none;
		padding-left: 0px;
	}
	
	ul#utility_links li#link_share {
		padding-right: 2px;
	}
	
	ul#utility_links li#link_share a {
		padding-right: 22px;
		background: url('../images/icon_share.png') 97px 0px no-repeat;
	}
	
	ul#utility_links li a {
		color: #790f6c;
	}

#isi_btn {
	float: left;
	width: 15.333333333333334%;
	display: block;
	padding-top: 42px;
}
	#isi_btn a {
		display: block;
		color: #fff;
		border-radius: 4px;	
		width: 100%;
		max-width: 128px;
		height: 48px;
		text-decoration: none;
		text-align: left;
		background: #a0298c;
	}
	
	#isi_btn .icon {
		float: left;
		margin: 7% 6.03125% 0 5.25%;
		width: 25%;
	}	
	
	#isi_btn .content {
		float: left;
		width: 58.25%;	
		font: 0.813em/1em "DIN Next W01 Bold";
		padding-top: 5px;
	}

#nav{
	background: #9a1d85;
	clear: both;
	width: 100%;
	display: block;
}

#nav_inner {
	margin: 0 auto;
	display: block;
	width: 80.58823529411765%;
	height: 50px;
	font-family: 'DIN Next W01 Regular';
}

/*HIDE MOBILE ELEMENTS*/
#nav .show-nav,
#nav #nav_reg {
	display: none;
}

#nav input[type=checkbox] {
	display: none;
	-webkit-appearance: none;
}

	ul#nav_links {
		list-style-type: none;
		/* margin: 0 0 0 2.125em; */
		margin-left: 0;
		padding: 0;
		display: block;
	}
	
	ul#nav_links li {
		float: left;
		height: 50px;
		font-size: 1em;	
		text-transform: uppercase;
		text-align: center;	
		margin: 0;
		padding: 0;
		position: relative;
	}
	
	ul#nav_links li.on {	
		font-family: 'DIN Next W01 Medium';
	}
	
ul#nav_links li.on:after,
ul#nav_links li.on:before,
ul#nav_links li.highlight:after,
ul#nav_links li.highlight:before {
	left: 50%;
	border: solid transparent;
	content: " ";
	height: 0;
	width: 0;
	position: absolute;
	pointer-events: none;
	z-index: 8;
}

ul#nav_links li.on:after,
ul#nav_links li.highlight:after {
	border-color: rgba(154, 29, 133, 0);
	border-top-color: #9a1d85;
	border-width: 14px;
	margin-left: -14px;
}

ul#nav_links li.on:before,
ul#nav_links li.highlight:before {
	border-color: rgba(154, 29, 133, 0);
	border-width: 15px;
	margin-left: -15px;
}

ul#nav_links li#nav_moa:hover.on:after,
ul#nav_links li#nav_moa:hover.on:before,
ul#nav_links li#nav_moa li.on:after,
ul#nav_links li#nav_moa li.on:before,
ul#nav_links li#nav_clinical:hover.on:after,
ul#nav_links li#nav_clinical:hover.on:before,
ul#nav_links li#nav_clinical li.on:after,
ul#nav_links li#nav_clinical li.on:before,
ul#nav_links li#nav_moa:hover.highlight:after,
ul#nav_links li#nav_moa:hover.highlight:before,
ul#nav_links li#nav_moa li.highlight:after,
ul#nav_links li#nav_moa li.highlight:before,
ul#nav_links li#nav_clinical:hover.highlight:after,
ul#nav_links li#nav_clinical:hover.highlight:before,
ul#nav_links li#nav_clinical li.highlight:after,
ul#nav_links li#nav_clinical li.highlight:before{
	border: none !important;
}
	
	/*
	#nav_moa {
		width: 17.956989247311828%;
	}
	
	#nav_clinical {
		width: 19.602150537634408%;
	}
	
	#nav_dosing {
		width: 26.007526881720432%;
	}
	
	#nav_access {
		width: 36.43333333333333%;
	}
	*/
	
	#nav_moa {
		width: 20%;
	}
	
	#nav_clinical {
		width: 26%;
	}
	
	#nav_dosing {
		width: 22%;
	}
	
	#nav_access {
		width: 32%;
	}
	
	ul#nav_links li a {
		color: #fff;
		text-decoration: none;
		display: block;
		padding: 16px 0 0 0;
		height: 50px;
	}	
	
	ul#nav_links li ul {
		margin: 0;
		padding: 0;
		display: none;
		list-style-type: none;
		position: relative;
		z-index: 10;
	}

	ul#nav_links li:hover ul {
		display: block;	
	}
	
	ul#nav_links li li {
		background: rgba(154,29,133,.9);
		font-size: 1em;	
		text-transform: none;
		text-align: left;	
		margin: 0;
		padding: 0;
		border: 1px solid #fff;
		border-top: 0px;
		width: 100%;
		height: auto;
		font-family: 'DIN Next W01 Regular';
	}
	
	ul#nav_links li li.on {
		background:rgba(73,63,117,.9);
	}
	
	ul#nav_links li li a {
		width: 100%;
		padding: 12px 8px !important;
		height: auto;
	}
	
	ul#nav_links li a:hover+.hidden, 
	.hidden:hover {
		display: block;
	}
	
	ul#nav_links li li ul {
		display: none !important;
	}
	
#main {	
	width: 80.58823529411765%;  
	margin: 0 auto;	
	border: 1px solid #fff;
	border-top: 0px;
	border-bottom: 0px;
	background: rgba(228,245,253,.8); /* Old browsers */
	/* IE9 SVG, needs conditional override of 'filter' to 'none' */
	background: url(data:image/svg+xml;base64,PD94bWwgdmVyc2lvbj0iMS4wIiA/Pgo8c3ZnIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyIgd2lkdGg9IjEwMCUiIGhlaWdodD0iMTAwJSIgdmlld0JveD0iMCAwIDEgMSIgcHJlc2VydmVBc3BlY3RSYXRpbz0ibm9uZSI+CiAgPGxpbmVhckdyYWRpZW50IGlkPSJncmFkLXVjZ2ctZ2VuZXJhdGVkIiBncmFkaWVudFVuaXRzPSJ1c2VyU3BhY2VPblVzZSIgeDE9IjAlIiB5MT0iMCUiIHgyPSIwJSIgeTI9IjEwMCUiPgogICAgPHN0b3Agb2Zmc2V0PSIwJSIgc3RvcC1jb2xvcj0iI2U0ZjVmZCIgc3RvcC1vcGFjaXR5PSIxIi8+CiAgICA8c3RvcCBvZmZzZXQ9IjEwMCUiIHN0b3AtY29sb3I9IiM4OWMzZGYiIHN0b3Atb3BhY2l0eT0iMSIvPgogIDwvbGluZWFyR3JhZGllbnQ+CiAgPHJlY3QgeD0iMCIgeT0iMCIgd2lkdGg9IjEiIGhlaWdodD0iMSIgZmlsbD0idXJsKCNncmFkLXVjZ2ctZ2VuZXJhdGVkKSIgLz4KPC9zdmc+);
	background: -moz-linear-gradient(top,  rgba(228,245,253,.8) 0%, rgba(137,195,223,.8) 100%); /* FF3.6+ */
	background: -webkit-gradient(linear, left top, left bottom, color-stop(0%,rgba(228,245,253,.8)), color-stop(100%,rgba(137,195,223,.8))); /* Chrome,Safari4+ */
	background: -webkit-linear-gradient(top,  rgba(228,245,253,.8) 0%,rgba(137,195,223,.8) 100%); /* Chrome10+,Safari5.1+ */
	background: -o-linear-gradient(top,  rgba(228,245,253,.8) 0%,rgba(137,195,223,.8) 100%); /* Opera 11.10+ */
	background: -ms-linear-gradient(top,  rgba(228,245,253,.8) 0%,rgba(137,195,223,.8) 100%); /* IE10+ */
	background: linear-gradient(to bottom,  rgba(228,245,253,.8) 0%,rgba(137,195,223,.8) 100%); /* W3C */
	padding-top: 20px;
	filter:none\9;
}

#sidebar {
	width: 21.083333333333332%;
	float: left;
	margin-top:4px;
	margin-right: 3.395833333333333%;
}
	#sidebar ul {
		list-style-type: none;
		margin: 0;
		padding: 0;	
	}

	.callout {
		border: 1px solid #fff;
		border-bottom: 0px;
		background: rgba(228,245,253,.5);  	
		padding: 10px 0;
	}
	
	.callout:first-child {
		-webkit-border-radius: 0 2px 0 0;
		border-radius: 0 2px 0 0;
	}
	
	.callout:last-child {
		border-bottom: 1px solid #fff;
		-webkit-border-radius: 0 0 2px 0;
		border-radius: 0 0 2px 1px;
	}
	.callout .icon {
		margin: 0 5.064516129032258% 0 2.6881720430107525%;
		width: 16.666666666666664%;	
		float: left;
	}
	
	.callout .content {
		width: 75.58064516129032%;
		float: left;
		padding-right: 8px;
	}
	
	.callout h3 {	
		font: 1.125em/1.333333333333333em "Neo Sans W02 Bold";
	}
	.callout h3 .reg{vertical-align:100%;}
	.callout p {
		font: 0.875em/1.285714285714286em "DIN Next W01 Regular";
	}
	
		.callout p .dinbold {
			font-family: "DIN Next W01 Bold";
		}
	
	.callout a {
		color: #920075;
		font: 0.875em/1em "DIN Next W01 Bold";
		padding-top: 20px;
	}

	#callout_order p {
		padding-bottom: 0;
	}

/* subnav for moa and clinical */
#sidebar ul.subnav {
	margin: 0 0 30px 0;
	border-bottom: 1px solid #fff;
}

#sidebar ul.subnav li ul {
	display: none;
}

#sidebar ul.subnav li.on ul {
	display: block;
}

.subnav li a {
	display: block;
	background: rgba(228,245,253,.5);	
	padding: 15px 10px 11px 20px;
	border: 1px solid #fff;
	border-bottom: 0px;
	font: 1em/1.125em "DIN Next W01 Medium";
	text-decoration: none;
	color: #9a1d85;
}

.subnav li.on > a {
	background: #fff;
	font-family: "DIN Next W01 Bold";
	color: #41306d;
}

.subnav li ul{
	display:none;
}
.subnav li.on ul{
	display:block;
}
.subnav li.on ul li a {
	padding-left: 34px;
}

/*
.subnav li.on ul li a:before {
	float: left;
	width: 18px;
	margin: 0 0 0 -18px;
	content: "–";
}
*/
/* end subnav */


#content_wrapper{
	width:/*75.52083333333334 725px*/72.12500000000001%;
	float:left;	
	padding-bottom:20px;
	margin-right:3.395833333333333%;
}
#content{
	font:1em/1.25 arial;	
}
#content h1{
	font-size:1.5em;
	line-height:1.25;
	font-family:"Neo Sans W02 Bold";	
	padding-bottom:30px;
}
#content h1 .reg{vertical-align:100%;}
#content h2{
	font-size: 1.188em;
	line-height: 1.157894736842105em;
	font-family: arial;
	font-weight: bold;
	padding-bottom:10px;
}

#content h3{
	font:1.188em/1.188 arial;
	font-weight:bold;	
	padding:35px 0 10px;
}
#content ul li{
	padding-bottom:10px;	
}
#content .graphic_left{
	float:left;
	margin-right:6.896551724137931%;/*25*/
	padding-bottom:22px;
}

#content .graphic{
	border:1px solid #fff;
	-webkit-border-radius: 1px 1px 1px 1px;
	border-radius: 1px 1px 1px 1px;
}

#mobile_sidebar{
	display:none;
}

#isi{
	font:1em/1.142857142857143 arial;
	padding:30px 0 20px 0;	
}

#isi .preheader-isi{
	color: #69b5dc;
	margin-left: -10px;
	font-size: 12px;
	padding-bottom: 0;
	font-style: italic;
}

#isi .footer-isi-container{
	padding: 20px 0 20px 0;
}

#isi .footer-isi-container p{
	padding: 0 0 0 5px;
}

#isi a{
	color:#920075;
	}
#isi .link_top.first{
	display:none;
}
#isi .link_top{
	float:right;
	font:1em/0.875em "DIN Next W01 Bold";	
	text-decoration:none;
	margin:0 20px 0 0;
}
#isi .link_top .caret{
	font-size:1.625em;
	line-height: 0.4230769230769231em;
	vertical-align: text-bottom;	
}

#isi h2{
	font:1.5em/0.7272727272727273em "DIN Next W01 Bold";
	padding:10px 0 10px 5px;
}
#isi p{
	padding:0 0 8px 5px;
}	
#isi p.last{
	display:block;
	float:left;
	}
#isi .boxed_warning{
	border:1px solid #41306d;
	font-weight:bold;
	margin:10px 0;
	padding:10px 5px 5px;
}
#isi .boxed_warning p{
	padding:0;
	}
#isi .boxed_warning li{
	padding:5px 0;
	}

#references{
	font:0.75em/1.166666666666667 arial;
}
#references p{
	padding:10px 0 20px 2px;	
}


#footer{
	display: block;
	font-family:arial;
	color:#3f2b56;
	padding:0 0 20px 0;
}
#footer_links{

	text-align:center;
	color:#9a1d85;
	list-style-type:none;
	padding:20px 0;	
}
#footer_links li {
	display: inline-block;
	padding:0 2px 0 5px;
	border-left:1px solid #9a1d85;
	font-size:0.688em;/*11px*/
	line-height:1em;
	}
	#footer_links li#footer_link_pi{
		border:none;
		padding-left:0px;
	}
	

#footer_logo_exl{
	float:left;
	width:72.16338880484115%;
	font:0.875em/1.285714285714286em arial;
	margin-top:20px;
}

#footer_logo_exl a.colorbox_interstitial {
	padding-right: 20px;
}

#footer_logo_exl img {
	vertical-align:bottom;
}

#footer_logo{
	float:left;
	margin:5px 0 0 0;
	width:27.83661119515885%;	
}


}



@media only screen and (min-width: 601px) and (max-width: 1094px) {

#header_logo {
	width: 31%;
}
#utility_nav {
	width: 43.60416666666667%;
}
.us_site {
	bottom: 35px;
	left: 0;
}
#isi_btn {
	width: 23.333333333333334%;
}
ul#utility_links{
	width:320px;	
}
ul#utility_links li#link_reg{
	border:0px;
	padding-left:0;
	padding-top:8px;
}

.callout h3{	
	font-size:1.063em;
	line-height:1.176470588235294em;
}
.callout p{
	font-size:0.813em;
	line-height:1.285714285714286em;
	padding:5px 0;
	}
.callout a{
	font-size:0.875em;
	line-height:1em;
	padding-top:10px;
}
	
}


@media only screen and (min-width: 601px) and (max-width: 959px) {
#footer_logo_exl {
font-size: 0.813em;
}
#footer_logo_exl img{
	width:30%;	
}

}

@media only screen and (min-width: 601px) and (max-width: 862px) {
	ul#nav_links li#nav_access a{padding-top:6px;}
}

@media only screen and (min-width: 601px) and (max-width: 845px) {
#footer_logo_exl {
font-size: 0.750em;
}
#footer_links{
	width:320px;
	margin:0 auto;	
}
li#footer_link_privacy{
	border:0px;
	padding-left:0px;	
}
#footer_logo{
	margin:11px 0 0 0;
}

}

@media only screen and (min-width: 601px) and (max-width: 820px) {

#header_logo {
	width: 34%;
}
ul#utility_links li#link_reg{
	padding-top:4px;
}
#utility_nav {
	width: 40.60416666666667%;
}
#isi_btn {
	width: 23.333333333333334%;
}
ul#utility_links{
	/* width:auto;	 */
	bottom: 14px;
}
ul#utility_links li{
	border:0px;
	padding-left:0;
	padding-top:3px;
	/* display:block; */
}
.subnav li a {
padding: 15px 20px 11px 10px;
}
.subnav li.on ul li a {
	padding-left: 20px;
}
.callout .icon{display:none;}
.callout .content{
	margin:0 3% 0 5%;
	width:92%;	
}

		
}

/* Tablet Layout: 601px to 768px. Inherits styles from: Desktop Layout. */

@media only screen and (min-width: 601px) and (max-width: 768px) {

#nav_inner,
#main{
	width:85.29411764705883%;
	margin:0 auto;
}

}
@media only screen and (min-width: 601px) and (max-width: 820px) {
	#header_inner{
		width: 98%;
	}
}


@media only screen and (min-width: 601px) and (max-width: 726px) {

ul#nav_links li#nav_access a{padding-top:8px;}
	
#footer_logo_exl {
font-size: 0.688em;
}
	
}


@media only screen and (min-width: 601px) and (max-width: 690px) {

.subnav li a {
	font-size:0.938em;
	line-height:1em;
}
ul#nav_links li li{
	font-size:0.938em;
}
.callout h3{	
	font-size:1em;
	line-height:1.25em;
}
.callout p{
	font-size:0.750em;
	line-height:0.8571428571428571em;
	padding:0;
	}
.callout a{
	font-size:0.750em;
	line-height:0.8571428571428571em;
	padding-top:10px;
}


	
}

@media only screen and (min-width: 601px) and (max-width: 630px) {

ul#nav_links li li{
	font-size:0.875em;
}

#footer_logo{
	margin:26px 0 0 0;
}

}